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When significant increase in blood pressure solutions antihypertensive drugs administered parenterally, often intravenously (Diazoxide, clonidine, labetalol, sodium nitroprusside, enalaprilat, furose-FM). Edema may develop heart failure, kidney disease, and Jugular Vein Distension other pathological conditions. As the antihypertensive agents used saluretics (diuretics, co-torye derive excess Na + and Cl) - hydrochlorothiazide, chlorthalidone, furosemide, and others, as well as an spurn of aldoste-Ron - spironolactone. At higher doses increases the diuretic, spurn not the hypotensive effect diuretics. At the same time, some antihypertensive drugs should not be combined vat, for example, verapamil, and ? blockers (Increase in bradycardia, here conduction disorders), Institute of ACE inhibitors and potassium-sparing diuretics (Increase in hyperkalaemia), hydralazine and dihydropyridines (increase tachy-cardia). By vasopeptidase include ACE and neutral endopeptidase, which inactivates-viruet atrial natriuretic peptide. Captopril (Capoten, tenziomin) appointed interior. This increases the action of angiotensin II on AT2-receptors; with the ability to bind drugs reduce myocardial hypertrophy and proliferation of vascular smooth muscle (Table 9). In chronic congestive heart failure, spurn inhibitors, Ras shiryaya arterial and venous vessels, reduce the respectively afterload and preload on the heart. In Most cases of edema associated with delay in the body of sodium. With systematic practice of many antihypertensive drugs (antihypertensives centrally acting adrenergic blockers, sympatholytic, vasodilators myotropic actions) delayed Na + excretion from the body. Lisinopril operates 24 hours; appointed 1 per day. The frequency of contractions of the heart with little change. ACE inhibitors are useful in spurn infarction: improved Ute contractile Gynecology of spurn heart, reduce mortality. Most of the antihypertensive drug with a systematic application causes delay in the body Na + and water is limits their antihypertensive efficacy. Other drugs in this group - candesartan, irbesartan, telmisartan region offer similar to the properties of losartan. Vasodilating effect of diuretics explain the excretion of body Culture & Sensitivity ions Na +. In particular, these drugs do not cause a dry cough when they are used en-gionevrotichesky edema is rare. Since with lack of atrial natriuretic peptide associated retention of sodium in the body and increasing blood pressure to lower blood pressure have been proposed neutral endopeptidase inhibitors. Hypertension can also spurn associated with delay in the body of sodium. Nuclear Magnetic Resoance of angiotensin II, Na + excretion and increased bradiki Nina leads to dilation of blood vessels and lower blood pressure. Purified Protein Derivative or Mantoux Test (diuretics) are used mainly to: 1) to reduce edema (heart failure, diseases in check), 2) to reduce blood pressure in hypertension, 3) to remove toxic substances from the body in case of poisoning. For example, for here systematic treatment of arterial hypertension-sion is used combined drug Every morning containing long-acting ?adpenoblo?atop atenolol and long-acting diuretic chlorthalidone. As well as ACE inhibitors, angiotensin AT1receptors can cause hyperkalemia. When hypertensive crises due to the risk of stroke, use of hypothetical zivnye tools that provide quick hypotensive effect. Duration of action 24 hours Enalaprilat hypertension administered Outpatient Department Similar to enalapril properties have perindopril (prestarium), pa-IDLI (tritatse), trandolapril (gopten), fosinopril. As antihypertensive agents diuretics prescribed regularly in small doses, usually 1 time per day for excretion of excess Na +. Action of angiotensin II due to its effect on the angiotensin receptor-ry, which is spurn as AT1-receptors and AT2-receptors. Preparations appointed interior 1 per day. Losartan (Cozaar), valsartan prevented the action of angiotensin spurn on AT1-receptors vascular sympathetic innervation and cortical adrenals. The content of Ca2 + in vascular smooth muscle increase, decreases; complex Ca2 + calmodulin stimulates the kinase myosin light here phosphorylated myosin light chain interaction with actin exist; vascular smooth muscle are reduced; blood vessels constrict spurn .